For Animal Health Only
ESTROPUR
Solution for Injection
COMPOSITION:
ESTROPURis a transparent, clear, colorless ready-to-use solution containing 0.075 mg per ml.
Contains R (D, +) Cloprostenol sodium salt and 1 mg Chlorocresol.
SPECIAL CLINICAL INFORMATION AND SPECIAL WARNINGS FOR TARGET SPECIES
• In order for prostaglandins to be effective, there must be a luteal structure in the ovary.
• Animals must have normal cycles for successful synchronization and cycle control.
• In the refractory period lasting 4-5 days after ovulation, prostaglandins are ineffective.
• Mares must be in true oestrus for the desired effect to be seen, cysts in their uterus
or in the presence of neoplasm cases, no response may be obtained from prostaglandin applications.
• It is necessary to define well the cyst structure formed in the ovary, prostaglandins in follicular cyst
the desired response is not received. Luteal cysts are successfully treated.
The general condition of the animals to which prostaglandin will be applied is correct and mineral matter.
have no shortcomings; If there are, take care to correct these conditions first.
should be displayed.
The rectal examination to be performed before the drug is administered is very important for the correct diagnosis and application. In this way, the risk of insemination of animals in anoestrus and pregnant animals is eliminated.
• Giving out some of the drug or giving it to the fat tissue during the injection may cause the desired result not to be obtained.
USE DURING PREGNANCY AND LACTATION
The preparation is designed to cause the elimination of the hormonal mechanism that maintains the pregnancy of pregnant animals and thus gives birth. It should not be administered to pregnant animals except in cases of terminating an unwanted pregnancy or initiating a controlled birth.
UNDESIRED/SIDE EFFECTS
Heat irregularities, abdominal pain and diarrhea can be seen in mares.
DRUG INTERACTIONS
The expected effect of ESTROPUR may be reduced when used with steroid or nonsteroidal anti-inflammatory drugs that inhibit endogenous prostaglandin synthesis.
SYMPTOMS OF OVERDOSE, PRECAUTIONS AND ANTIDOTE
ESTROPURIt has been tested for evaluation of possible side effects on the animal organism, acute toxicity and determination of tolerance. When examining the tolerance of the tested preparation, no general or local changes were found in the genital organs of the lactating cow by clinical examination.
There was no negative cloprostenol sodium salt effect in lactating cows when ten times the dose was administered within 10 days. The increase in heart rate is temporary. Biochemical indicators did not change significantly during the experiment.
WARNINGS ABOUT DRUG RESIDUES IN FOOD
Drug residue washout time (withdrawal); During the treatment and after the last drug administration, cattle should not be sent to slaughter before 1 day has passed. The residual purification period for milk is 0 days.
GENERAL WARNINGS
- _cc781905-5cde-3194-bb3b-136bad-136bad5cf3b-13659c133655cc-bb3b-fbc-136bad5cf1365cf583153594cc781905-5cde-3194-bb3b-136bad-136bad5cf136558d_583136359cc7819055cf78359cc781905cc78d359cc781905 -5cde-3194-bb3b-136bad5cf58d_ _cc781905-5cde-3194-bb3b-136ba5cf58d_ Consult your veterinarian before use and any unexpected effects
- _cc781905-5cde-3194-bb3b-136bad-136bad5cf3b-13659c133655cc-bb3b-fbc-136bad5cf1365cf583153594cc781905-5cde-3194-bb3b-136bad-136bad5cf136558d_583136359cc7819055cf78359cc781905cc78d359cc781905 -5cde-3194-bb3b-136bad5cf58d_ Keep out of the reach of children and away from foodstuffs.
- _cc781905-5cde-3194-bb3b-136bad-136bad5cf3b-13659c133655cc-bb3b-fbc-136bad5cf1365cf583153594cc781905-5cde-3194-bb3b-136bad-136bad5cf136558d_583136359cc7819055cf78359cc781905cc78d359cc781905 -5cde-3194-bb3b-136bad5cf58d_ Do not buy products with expired shelf life and do not use damaged packaging.
PRECAUTIONS TO BE TAKEN BY THE APPLICANT AND WARNINGS FOR PHYSICIANS
Prostaglandin can be absorbed through the skin, so especially women of childbearing age, pregnant women and asthmatics should be cautious in the use of this product. In case of accidental spillage on the skin, it should be washed off immediately with water.
Prostaglandins of the F2alpha type can cause bronchospasm in humans. In case of respiratory distress caused by accidental inhalation or injection, bronchodilators such as isoprenaline or salbutamol must be rapidly inhaled.
Estropur
Her 1 ml’de 0,075 mg Kloprostenol ( = 0.079 mg R (D,+) Kloprostenol sodyum tuzu) ve antimikrobiyal koruyucu olarak 1 mg Klorokrezol içeren berrak, renksiz, kullanıma hazır, steril bir enjeksiyonluk çözeltidir.