TOXIC

USED ONLY FOR ANIMAL HEALTH

TOP SPOT ON 650 MG

Dropping Solution

COMPOSITION:

For every 1 ml:

Active ingredient:

permethrin 650mg

Excipients:

Butylparaben 1.0 mg

Butyl hydroxyanisole (E320) 0.2 mg

Butyl hydroxytoluene (E321) 0.1 mg

It is a yellowish clear solution.

USE IN PREGNANCY AND LACTATION

No pharmacovigilance effects have been reported in animals used during pregnancy and lactation. However, since the safety of the product has not been proven in pregnant and lactating animals, use should only be made after the evaluation of the benefit / risk ratio determined by the responsible Veterinarian.

UNDESIRED EFFECTS

Transient skin irritation may occur at the application site. In such cases, clean the animal with water.rinse and protect against cold. Consult a Veterinarian if the undesirable effect persists.

DRUG INTERACTIONS

Pyrethrins and pyrethroids can be formulated with synergists (Piperonyl butoxide N-octyl bicycloheptene dicarboxamide) and/or insect growth regulators (Pyriproxifen) to increase the activity of insecticides. Permethrin; It provides excellent efficacy together with dinotefuran, imidacloprid, fipronil. Toxic effects may increase following simultaneous exposure to organophosphates or other synthetic pyrethroids. Do not use with other ectoparasites as it may cause toxicity.Do not use with other topically applied products. In the absence of appropriate information, no other insecticide should be used during Top Spot On treatment.

SYMPTOMS OF OVERDOSE, PRECAUTIONS AND ANTIDOTE

The recommended dose should be applied. Local irritation of the skin, numbness, itching, tingling and burning in overdosechange in sensitivityit could be. If the drug is injected into the eye, lacrimation and transient conjunctivitis may occur. In case of accidental contact with the eyes, the eyes should be washed with plenty of water. If the drug causes irritation at the application site, the animal should be washed with clean water. The product has an irritating effect on the respiratory tract. Cough, sneezing and runny nose may occur. Ingestion of the drug is followed by nausea, vomiting and abdominal pain, as well as pain in the throat. Ulcers may form in the mouth and salivation increases. Systemic symptoms (Vertigo, headache and fatigue, palpitations, chest pain and blurred vision) occur 4 to 48 hours after exposure. Coma and cramps can be life threatening. If systemic symptoms are present, a Veterinarian should be consulted.There is no known specific antidote; If possible signs of overdose occur, the animal should be treated symptomatically.

WARNINGS ABOUT DRUG RESIDUES IN FOOD

Not intended for animals bred for food.

GENERAL WARNINGS

It is poisonous.

Consult your Veterinarian before use.

Keep out of reach of children.

Consult your Veterinarian in case of an unexpected effect.

Top Spot On

Horse and Cat
Pharmacotherapeutic group: Pyrethrins and pyrethroids

ATCvet code: QP53AC04

Pharmacodynamic properties

Permethrin is a Type I synthetic pyrethroid used in Veterinary Medicine as four different isomers ([1R, trans], ([1R, cis], ([1S, trans], ([1S, cis]). Reduction of Na+ and K+ ions in the membranes of neurons, resulting in depolarization and increased release of neurotransmitters and development of neuromuscular block in ectoparasites. It has an adulticide (to kill adult parasites) effect against ectoparasites. It is an ectoparasitic drug with very good efficacy. The excipients have the depot effect of the product. The product, which contains a good combination of excipients, creates a system that allows the active substance to be absorbed into the upper skin layers (Corneum layer, the uppermost layer of the epidermis) where a storage is made.The product is then released from the storage area surrounding the application site for a long time .

Pharmacokinetic properties

Permethrin is practically non-toxic to mammals and birds because it degrades very quickly to biologically inactive metabolites due to the rapid metabolism of these animals. Permethrin is contraindicated in cats because of deficiency of glucuronidase transferase enzyme. Oral LD50 value of permethrin is 430-4000 mg/kg in rats. When given intravenously, this LD50 value is above 270 mg/kg. The skin LD50 value is over 4000 mg/kg in rats and over 2000 mg/kg in rabbits.

Permethrin is neither teratogenic nor mutagenic. Absorbed permethrin is metabolized in the mammalian liver as several metabolites such as phenoxybenzyl alcohol or dichlorophenyl acid, which are oxidized to phenoxybenzoic acid. Dichlorophenyl acid and phenoxybenzoic acid then combine with glucuronic acid and are excreted in the bile. Permethrin and its metabolites are excreted in the urine and feces.
It is used only by applying to the skin by drip method.For dogs, hold the neck of the tube up and tap the neck of the tube repeatedly with your finger. Carefully break off the end of the tube with a twisting motion. Separate the animal's hair from the area between the scapula so that the skin is visible. DPlace the tip of the tube directly on the skin and squeeze the tube repeatedly to completely empty the contents.. Do not rub.

For equine treatment, first separate the hair and apply the solution directly to the skin.Do not rub.

It is important that the application is made to the designated area and that animals do not lick each other or the application areas after the application. If animals are soaked or shampooed after treatment, the treatment needs to be repeated. The interval between each treatment should be at least 7 days.

Dogs:Its pharmacological dose is 43.4 mg/kg body weight.

Less than 15 kg: The contents of 1 tube (1 ml) are applied to the skin between the shoulder blades in small dogs.a tube from the arrow pack).

Between 15-30 kg: In medium-sized dogs, the contents of 2 tubes (2 x 1 ml) are applied to the skin between the shoulder blades and to the root of the tail (Çtwo tubes from the arrow pack).

Over 30 kg: In large dogs, 3 tubes (3 x 1 ml) are applied to the skin between the shoulder blades, the middle of the back and the root of the tail.three tubes from the arrow pack).

Horses: Its pharmacological dose is 32.5 mg/kg body weight.

A 25 ml pack is sufficient for a horse with a live weight of 500 kg. The drug is applied to one point, 2-3 ml, to the area between the horse's scapula and to various places on the skin in the lumbar region.

Top Spot On

Target Species

Positioning

Pharmacological Properties

Usage Area and Indications

Usage and Dosage